Tirano lies in the upper Valtellina at the entrance to Val Poschiavo. The Rhaetian Railway's Bernina Railway has been running to this small town situated in the Italian province of Sondrio since 1908. This is where Bernina Express passengers change to the Bernina Express Bus to continue their journey to Lugano back in Switzerland. The town's landmark is the 16th century church of the Madonna of Tirano.